3-Aminopyridine → HCID 58459380, compound

HRID 2036677Notes

Reaction equation

HRID 2036677 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[N+:10]([O-:12])=[O:11].[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[CH:14]=1>>[F:9][C:4]1[C:3]([N+:10]([O-:12])=[O:11])=[C:2]([NH:19][C:15]2[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=2)[CH:7]=[C:6]([F:8])[CH:5]=1

Participants

3

Reactant 2

HCID 100093-AminopyridineHCID 675671,3,5-Trifluoro-2-nitrobenzene

Product 1

HCID 58459380HCID 58459380, compound

Procedure

Prepared according to Step D1 in General Procedure D using 1,3,5-trifluoro-2-nitrobenzene (5.28 mL, 45.2 mmol) and pyridin-3-amine (4.25 g, 45.2 mmol) to give N-(3,5-difluoro-2-nitrophenyl)pyridin-3-amine as a yellow solid. LC-MS (ESI) m/z 252.1 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c7419701162e4f7ea5afba7f1c8109a1
Source dataset
uspto-grants-2013_11
Patent number
US08575183B2

Reaction notes

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