Potassium Cation → 5-Bromo-4'-methoxy-3H-spiro[benzofuran-2,1'-cyclohexan]-3-one

HRID 203675Notes

Reaction equation

HRID 203675 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8](=[O:9])[C:10]2([OH:18])[CH2:11][CH2:12][CH:13]([O:16][CH3:17])[CH2:14][CH2:15]2)[cH:7]1.[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[CH3:20][C:21]([CH3:22])([O-:23])[CH3:24].[K+:25]>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[C:8](=[O:9])[C:10]1([CH2:11][CH2:12][CH:13]([O:16][CH3:17])[CH2:14][CH2:15]1)[O:18]2

Participants

5

Reactant 4

HCID 813Potassium CationHCID 8028TetrahydrofuranHCID 45749132-Methylpropan-2-olateHCID 67979505(5-Bromo-2-fluorophenyl)(1-hydroxy-4-methoxycyclohexyl)methanone

Product 1

HCID 581975515-Bromo-4'-methoxy-3H-spiro[benzofuran-2,1'-cyclohexan]-3-one

Sources & evidence

ORD record
ord-893d4419d5cc46b985949022e82dcee6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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