HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 44205199, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-(1H-indol-3-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide | HCID 86656589 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 44205199 | HCID 44205199 | 63% |
Reaction Steps
180 mg 2-(1H-indol-3-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide are dissolved in methanol and 6 ml of a solution of 0.1 M HCl in water are added drop wise. The mixture is stirred overnight. The mixture is evaporated in vacuo and the residue is treated with a mixture of water and acetonitrile and lyophilized. 92 mg (63%) of the title compound are obtained. MH+=350.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575193B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-cc6f4025a0a640ce9e13531d95c22cdd |
| Source note | uspto-grants-2013_11 |