Hydrochloric Acid → HCID 44205199, compound

HRID 2036855Notes

Reaction equation

HRID 2036855 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]([N:13]2[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:23]([NH:25][O:26]C4CCCCO4)=[O:24])[CH:19]=3)[CH2:14]2)=[O:12])=[CH:2]1.[ClH:33]>CO.O>[ClH:33].[OH:26][NH:25][C:23]([C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[CH2:14][N:13]([C:11](=[O:12])[CH2:10][C:3]1[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=1)[CH2:22][CH2:21]2)=[O:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 866565892-(1H-indol-3-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide

Product 1

HCID 44205199HCID 44205199, compoundYield 63%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

180 mg 2-(1H-indol-3-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide are dissolved in methanol and 6 ml of a solution of 0.1 M HCl in water are added drop wise. The mixture is stirred overnight. The mixture is evaporated in vacuo and the residue is treated with a mixture of water and acetonitrile and lyophilized. 92 mg (63%) of the title compound are obtained. MH+=350.0

Workup

  1. customThe mixture is evaporated in vacuo
  2. additionthe residue is treated with a mixture of water and acetonitrile

Sources & evidence

ORD record
ord-cc6f4025a0a640ce9e13531d95c22cdd
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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