HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Cyclobutylcarbonyl)-N-hydroxy-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-(cyclobutylcarbonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide | HCID 86656592 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(Cyclobutylcarbonyl)-N-hydroxy-1,2,3,4-tetrahydroisoquinoline-6-carboxamide | HCID 44230390 | — |
Reaction Steps
160 mg of 2-(cyclobutylcarbonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide and 2 ml of a 0.1M solution of HCl in water in 2 ml methanol are stirred overnight at ambient temperature. The reaction mixture is evaporated and the residue is treated with acetonitrile. 53 mg of nearly colorless crystals are obtained. MH+=275.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575193B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ecee488d377c4878a3ac5053e5573711 |
| Source note | uspto-grants-2013_11 |