HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N6-Hydroxy-N2-(3-methoxypropyl)-3,4-dihydroisoquinoline-2,6(1H)-dicarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N2-(3-methoxypropyl)-N6-(tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroisoquinoline-2,6(1H)-dicarboxamide | HCID 86656594 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N6-Hydroxy-N2-(3-methoxypropyl)-3,4-dihydroisoquinoline-2,6(1H)-dicarboxamide | HCID 44230392 | 81.4% |
Reaction Steps
A mixture of 180 mg of N2-(3-methoxypropyl)-N6-(tetrahydro-2H-pyran-2-yloxy)-3,4-dihydroisoquinoline-2,6(1H)-dicarboxamide in 4 ml methanol and 6 ml of an aqueous 0.1 N HCl is stirred overnight at ambient temperature and evaporated. The residue is dissolved in acetonitrile and water and lyophilized. 115 mg of the title compound are obtained. MH+=308.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575193B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-24563de0b55948c9b04b76596b2c65b3 |
| Source note | uspto-grants-2013_11 |