Hydrochloric Acid → HCID 86656598, compound

HRID 2036862Notes

Reaction equation

HRID 2036862 reaction equation
[CH3:1][N:2]([CH3:28])[CH2:3][CH2:4][CH2:5][C:6]([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:18]([NH:20][O:21]C3CCCCO3)=[O:19])[CH:14]=2)[CH2:9]1)=[O:7].[ClH:29]>CO>[ClH:29].[CH3:28][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:18]([NH:20][OH:21])=[O:19])[CH:14]=2)[CH2:9]1)=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86656599HCID 86656599, compound

Product 1

HCID 86656598HCID 86656598, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 35 mg 2-[4-(dimethylamino)butanoyl]-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide, 1 ml methanol and 1.5 ml 0.1N, aqueous HCl is stirred for 3 h at ambient temperature. Subsequently, the mixture is lyophilized. 40 mg of a colorless solid are obtained. MH+=306.1

Sources & evidence

ORD record
ord-e17d72856d2c494880bbaee67115c716
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

Loading…