Hydrochloric Acid → HCID 86656600, compound

HRID 2036863Notes

Reaction equation

HRID 2036863 reaction equation
[CH3:1][C:2]1[N:3]([CH2:7][C:8]([N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]([NH:22][O:23]C4CCCCO4)=[O:21])[CH:16]=3)[CH2:11]2)=[O:9])[CH:4]=[CH:5][N:6]=1.[ClH:30]>CO>[ClH:30].[OH:23][NH:22][C:20]([C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[CH2:11][N:10]([C:8](=[O:9])[CH2:7][N:3]1[CH:4]=[CH:5][N:6]=[C:2]1[CH3:1])[CH2:19][CH2:18]2)=[O:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86656601HCID 86656601, compound

Product 1

HCID 86656600HCID 86656600, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 18 mg 2-[(2-methyl-1H-imidazol-1-yl)acetyl]-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide, 1 ml methanol and 1.5 ml 0.1N aqueous HCl is stirred for 3 h at ambient temperature. The reaction mixture is then lyophilized. 18 mg of the title compound are obtained as colorless solid. MH+=329.1

Sources & evidence

ORD record
ord-90d959dacb82411f8b129cea624aeb03
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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