HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-But-2-ynoyl-N-hydroxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-but-2-ynoyl-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide | HCID 86656606 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-But-2-ynoyl-N-hydroxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide | HCID 44229347 | 78% |
Reaction Steps
A mixture of 124 mg 2-but-2-ynoyl-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide, 6 ml methanol and 6 ml 0.1 N aqueous hydrochloric acid is stirred overnight at ambient temperature. The mixture is evaporated and the residue is treated with water and acetone. A colorless solid separates. After drying, 73 mg of the title compound are obtained. MH+=275.7
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575193B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-b36085de4303449289427bd715b1ef79 |
| Source note | uspto-grants-2013_11 |