反应详情

A mixture of 124 mg 2-but-2-ynoyl-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide, 6 ml methanol and 6 ml 0.1 N aqueous hydrochloric acid is stirred overnight at ambient temperature. The mixture is evaporated and the residue is treated with water and acetone. A colorless solid separates. After drying, 73 mg of the title compound are obtained. MH+=275.7

1. customThe mixture is evaporated
2. additionthe residue is treated with water and acetone
3. customAfter drying