HCID 67345002, compound → HCID 58399186, compound

HRID 2036880Notes

Reaction equation

HRID 2036880 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13]C)=[O:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16]>C1COCC1>[CH2:18]([O:17][C:15]([N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[C:7]([C:11]([OH:13])=[O:12])[CH:6]=2)[CH2:1]1)=[O:16])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 1

HCID 67345002HCID 67345002, compound

Product 1

HCID 58399186HCID 58399186, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 14.2 g 2-benzyl 6-methyl 3,4-dihydroisoquinoline-2,6(1H)-dicarboxylate, 50 ml THF and 32 ml of a 2M aqueous LION solution is stirred at ambient temperature overnight. The reaction mixture is added to 50 g of ice and the pH as adjusted to 2. The organic phase is separated, dried, and evaporated. 13.59 g of a colorless solid are obtained.

Workup

  1. customThe organic phase is separated
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-6581a463a4814946bb4e1162ffbf67bf
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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