反应详情

At 0° C. a mixture of 16.93 g 2-tert-butyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate, 160 ml dichloromethane and 80 ml trifluoroacetic acid is stirred for 30 min. Then, the mixture is stirred for 5 h at ambient temperature. The reaction mixture is evaporated and the residue is treated with a 10% KOH solution and dichloromethane. The organic layer is dried and evaporated. 22.18 g of the title compound are obtained.

1. stirringThen, the mixture is stirred for 5 h at ambient temperature
2. customThe reaction mixture is evaporated
3. additionthe residue is treated with a 10% KOH solution and dichloromethane
4. customThe organic layer is dried
5. customevaporated