Tetrahydrofuran → HCID 66880738, compound

HRID 2036911Notes

Reaction equation

HRID 2036911 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([OH:13])=[O:12])[CH:9]=2)[CH2:4][CH2:3][NH:2]1.C1C[O:17][CH2:16][CH2:15]1>>[C:16]([N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][C:8]([C:11]([OH:13])=[O:12])=[CH:7][CH:6]=2)[CH2:1]1)(=[O:17])[CH3:15]

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 41783081,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid

Product 1

HCID 66880738HCID 66880738, compound

Procedure

30.6 g 1,2,3,4-tetrahydro-7-isoquinolinecarboxylic acid are dissolved in 383 ml THF 109 ml acetic acid anhydride are added and the mixture is stirred for 5 h at ambient temperature. The resulting solid is collected and dried. 12.1 g of a colorless solid are obtained.

Workup

  1. additionare added
  2. customThe resulting solid is collected
  3. customdried

Sources & evidence

ORD record
ord-69845303df3543f393a13ee4a6d47d0f
Source dataset
uspto-grants-2013_11
Patent number
US08575193B2

Reaction notes

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