Trifluoroacetic acid → HCID 44514773, compound

HRID 2037069Notes

Reaction equation

HRID 2037069 reaction equation
[N:1]1([C:7]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:29])[NH:21][C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=4)=[CH:15][CH:14]=3)[N:10]=[C:9]([NH:30][CH:31]3[CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32]3)[N:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:33]1[CH2:34][CH:31]([NH:30][C:9]2[N:8]=[C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH:21][C:22]4[CH:23]=[CH:24][C:25]([CH3:28])=[CH:26][CH:27]=4)=[O:29])=[CH:15][CH:14]=3)[N:10]=2)[CH2:32]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 44514485HCID 44514485, compound

Product 1

HCID 44514773HCID 44514773, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of tert-butyl 3-[(4-morpholin-4-yl-6-{4-[(4-methyl-phenylcarbamoyl)amino]phenyl}-1,3,5-triazin-2-yl)amino]azetidine-1-carboxylate 130 mg (0.23 mmoles) in DCM, (20 ml) TFA (1.5 ml) was added at room temperature and stirred for 24 hours. At the end, reaction mixture was concentrated and purified by Gilson HPLC, using ACN/water and TFA. Yield: 40 (37%); (M+H) 461.5.

Workup

  1. customAt the end, reaction mixture
  2. concentrationwas concentrated
  3. custompurified by Gilson HPLC

Sources & evidence

ORD record
ord-519be736e9e2439981ba196c80192eef
Source dataset
uspto-grants-2013_11
Patent number
US08575159B2

Reaction notes

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