Hydrazine hydrate (1:1) → HCID 178501755, compound

HRID 2037180Notes

Reaction equation

[CH3:1][C:2]([CH3:36])([CH3:35])[C:3]([C:5]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])[N:8]([C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:32]=[CH:31][S:30][CH:29]=3)=[CH:24][CH:23]=2)[C:7](=[O:33])[C:6]=1O)=O.O.[NH2:38][NH2:39].C(=O)(O)[O-].[Na+]>C(O)(=O)C>[C:2]([C:3]1[C:5]2[CH:9]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[O:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])[N:8]([C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:32]=[CH:31][S:30][CH:29]=4)=[CH:24][CH:23]=3)[C:7](=[O:33])[C:6]=2[NH:38][N:39]=1)([CH3:36])([CH3:35])[CH3:1]

Participants

Conditions

Temperature: 95 °C

Procedure

A mixture of 4-(2,2-dimethylpropionyl)-3-hydroxy-5-(2-methoxycarbonylmethyloxyphenyl)-1-(4-thiophene-3-ylphenyl)-1,5-dihydropyrrole-2-one (0.207 g, 0.41 mmol), hydrazine hydrate (0.022 mL, 0.45 mmol) and acetic acid (3.1 mL) was stirred at 95° C. for 1 hour. After the reaction was completed, saturated sodium bicarbonate solution was poured into the reaction mixture, and the mixture was extracted with chloroform. The extract was washed with brine, dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was triturated with ethyl ether and diisopropyl ether to give 3-t-butyl-5-(4-thiophene-3-ylphenyl)-4-(2-methoxycarbonylmethyloxyphenyl)-4,5-dihydro-1H-pyrrolo[3,4-c]pyrazole-6-one (0.191 g, yield: 93%) as pale brown solid.

Workup

extractionthe mixture was extracted with chloroform
washThe extract was washed with brine
dry with materialdried over anhydrous sodium sulphate
concentrationconcentrated in vacuo
customThe resulting residue was triturated with ethyl ether and diisopropyl ether

Sources & evidence

ORD record: ord-7fb90f61bbd44758a3f72a5f0f8a8d8a
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575197B2

Reaction notes

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