反应详情

温度

100 °C

A mixture of 2-chloro-4-phenylthiazole (300 mg, 1.5 mmol), 4-amino-2-phenyl-butan-2-ol (294 mg, 1.5 mmol) and DBU (1.5 mL) was heated to 100° C. under N2 in a microwave for 2 h. After the material was consumed, the mixture was neutralized with 1 N HCl solution (5 mL), extracted with CH2Cl2 (3×5 mL). The combined organic extracts were dried over Na2SO4 and concentrated to leave a residue, which was purified by column chromatography (1:2 petroleum ether/EtOAc) to afford 2-phenyl-4-(4-phenylthiazol-2-ylamino)butan-2-ol (100 mg, 20%).

1. customAfter the material was consumed
2. extractionextracted with CH2Cl2 (3×5 mL)
3. dry with materialThe combined organic extracts were dried over Na2SO4
4. concentrationconcentrated
5. customto leave a residue, which
6. customwas purified by column chromatography (1:2 petroleum ether/EtOAc)