Piperazin-2-one → HCID 58109224, compound

HRID 2037605Notes

Reaction equation

HRID 2037605 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]2[CH2:15][CH2:14][C@@:13]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)([CH2:16][CH2:17]O)[O:12][C:11]2=[O:26])[CH3:9])=[CH:4][CH:3]=1.[NH:27]1[CH2:32][CH2:31][NH:30][CH2:29][C:28]1=[O:33]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]([N:10]2[CH2:15][CH2:14][C@@:13]([C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)([CH2:16][CH2:17][N:30]3[CH2:31][CH2:32][NH:27][C:28](=[O:33])[CH2:29]3)[O:12][C:11]2=[O:26])[CH3:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 58109626HCID 58109626, compound

Product 1

HCID 58109224HCID 58109224, compound

Procedure

The title compound was prepared from (S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one and piperazin-2-one following procedures analogous to those described in Example 178. LC-MS Method 2 tR=1.117 min, m/z=506; 1H NMR (CDCl3) 1.42 (d, 3H), 2.16-2.35 (m, 5H), 2.75-2.88 (m, 2H), 3.17-3.40 (m, 3H), 3.56-3.80 (m, 4H), 5.45 (m, 1H), 5.61-6.52 (s, 2H), 6.78 (d, 2H), 7.01-7.24 (m, 6H).

Sources & evidence

ORD record
ord-3842daf60e6041a3a304ff5d82f7cb1a
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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