Morpholine → HCID 58109503, compound

HRID 2037676Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C@@H:14]([N:16]3[CH2:21][CH2:20][C@:19]([CH2:28][CH2:29]O)([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[O:18][C:17]3=[O:31])[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[NH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C@@H:14]([N:16]3[CH2:21][CH2:20][C@:19]([CH2:28][CH2:29][N:32]4[CH2:37][CH2:36][O:35][CH2:34][CH2:33]4)([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[O:18][C:17]3=[O:31])[CH3:15])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 53473136HCID 53473136, compound

Product 1

HCID 58109503HCID 58109503, compound

Procedure

The title compound was prepared from (S)-3-((S)-1-(4′-fluorobiphenyl-4-yl)ethyl)-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one and morpholine following procedures analogous to those described in Example 178. LC-MS Method 2 tR=1.19 min, m/z=511.2; 1H NMR (CDCl3) 1.49 (t, 3H), 2.05-2.11 (m, 3H), 2.16 (m, 1H), 2.23-2.41 (m, 5H), 2.51 (m, 1H), 2.71 (m, 1H), 3.61 (m, 4H), 5.61 (m, 1H), 6.83 (d, 2H), 7.20-7.32 (m, 4H), 7.31 (m, 5H), 7.43 (m, 2H).

Sources & evidence

ORD record: ord-50b5667f0a424b01b8906f04e17f5345
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575156B2

Reaction notes

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