Morpholine → HCID 58109503, compound

Participants

Reaction Steps

The title compound was prepared from (S)-3-((S)-1-(4′-fluorobiphenyl-4-yl)ethyl)-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one and morpholine following procedures analogous to those described in Example 178. LC-MS Method 2 tR=1.19 min, m/z=511.2; 1H NMR (CDCl3) 1.49 (t, 3H), 2.05-2.11 (m, 3H), 2.16 (m, 1H), 2.23-2.41 (m, 5H), 2.51 (m, 1H), 2.71 (m, 1H), 3.61 (m, 4H), 5.61 (m, 1H), 6.83 (d, 2H), 7.20-7.32 (m, 4H), 7.31 (m, 5H), 7.43 (m, 2H).

Provenance & Evidence