HCID 58109450, compound → HCID 58109599, compound

HRID 2037755Notes

Reaction equation

HRID 2037755 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]2[CH2:15][CH2:14][C@:13]([CH2:23][CH2:24]C(N)=O)([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)[O:12][C:11]2=[O:28])[CH3:9])=[CH:4][CH:3]=1>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]2[CH2:15][CH2:14][C@:13]([CH2:23][CH2:24][NH:10][C:11](=[O:28])[O:12][CH2:13][CH3:14])([C:16]3[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=3)[O:12][C:11]2=[O:28])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 58109450HCID 58109450, compound

Product 1

HCID 58109599HCID 58109599, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 3-((R)-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)propanamide following a procedure analogous to that described in Example 612 using ethanol as solvent. LC-MS Method 1 tR=1.83 min, m/z=493, 495 (M+1); 1H NMR (CD3OD) 7.25-7.20 (m, 4H), 7.03 (t, J=8.8 Hz, 2H), 6.81 (d, J=8.2 Hz, 2H), 5.41 (q, J=7.3 Hz, 1H), 3.91 (q, J=7.2 Hz, 2H), 3.10-3.00 (m, 2H), 2.90-2.85 (m, 1H), 2.38-2.34 (m, 1H), 2.22-2.14 (m, 2H), 2.01 (t, J=7.6 Hz, 2H), 1.42 (d, J=7.3 Hz, 3H), 1.10 (t, J=7.2 Hz, 3H).

Sources & evidence

ORD record
ord-d9d88795720840948c0b0b2d2637c9a3
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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