2,2,2-Trifluoroethyl trifluoromethanesulfonate → 5-Bromo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

HRID 2037783Notes

Reaction equation

HRID 2037783 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.FC(F)(F)S(O[CH2:15][C:16]([F:19])([F:18])[F:17])(=O)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[N:6]([CH2:15][C:16]([F:19])([F:18])[F:17])[CH:7]=1

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 5995285-Bromo-2-hydroxypyridine

Product 1

HCID 534080995-Bromo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

Procedure

5-bromo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one was prepared from 5-bromopyridin-2(1H)-one and 2,2,2-trifluoroethyl trifluoromethanesulfonate following a procedure analogous to that described in Example 628 Step 1.

Sources & evidence

ORD record
ord-be28a48766f947149316cfaf1b0b33be
Source dataset
uspto-grants-2013_11
Patent number
US08575156B2

Reaction notes

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