反应详情

In two separate runs, dissolve (R)-2-phenoxymethyl-oxirane (1.410 g, 9.389 mmol) in tetrahydrofuran (50 mL). Add 5% ruthenium on carbon (0.71 g) and hydrogenate at 60 psi of hydrogen gas for 40 minutes. Filter through a filtering agent, wash with tetrahydrofuran, concentrate and purify (silica gel chromatography, eluting with 5:95 to 30:70 ethyl acetate:hexanes) to give the desired compound as a clear liquid (0.850 g, 57.9% combined yield).

1. customIn two separate runs
2. filtrationFilter through a filtering agent
3. washwash with tetrahydrofuran
4. concentrationconcentrate
5. custompurify
6. wash(silica gel chromatography, eluting with 5:95 to 30:70 ethyl acetate:hexanes)