反应详情

10 g of 2-(1-imidazolylcarbonylamino)-6-methyl-4[1H]-pyrimidinone are added to a solution of 6.12 g of bis(3-aminopropyl)dimethylammonium chloride dihydro-chloride (22.8 mmol) and 5.9 g of diisopropylethylamine (45.6 mmol) in 500 ml of ethanol. The solution is stirred at reflux for 24 hours. The product is precipitated from ethanol, filtered under hot conditions, and then dried under reduced pressure. 6 g (20.2 mmol) of compound are obtained in the form of a white powder, with a yield of 53%.

1. temperatureat reflux for 24 hours
2. customThe product is precipitated from ethanol
3. filtrationfiltered under hot conditions
4. customdried under reduced pressure