Diisopropylethylamine → HCID 178429406, compound

HRID 2038153Notes

Reaction equation

HRID 2038153 reaction equation
[N:1]1([C:6]([NH:8][C:9]2[NH:10][C:11]([CH3:16])=[CH:12][C:13](=[O:15])[N:14]=2)=[O:7])[CH:5]=[CH:4]N=C1.[ClH:17].Cl.[Cl-].NCC[CH2:23][N+:24]([CH2:27][CH2:28][CH2:29][NH2:30])([CH3:26])[CH3:25].C([N:34]([CH:37]([CH3:39])[CH3:38])[CH2:35]C)(C)C>C(O)C>[Cl-:17].[CH3:26][N+:24]([CH3:23])([CH2:25][CH2:4][CH2:5][NH:1][C:6]([NH:8][C:9]1[NH:10][C:11]([CH3:16])=[CH:12][C:13](=[O:15])[N:14]=1)=[O:7])[CH2:27][CH2:28][CH2:29][NH:30][C:6]([NH:1][C:35]1[NH:34][C:37]([CH3:38])=[CH:39][C:13](=[O:15])[N:14]=1)=[O:7]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 86656190Bis(3-aminopropyl)dimethylammonium chloride dihydro-chlorideHCID 178429402HCID 178429402, compound

Product 1

HCID 178429406HCID 178429406, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g of 2-(1-imidazolylcarbonylamino)-6-methyl-4[1H]-pyrimidinone are added to a solution of 6.12 g of bis(3-aminopropyl)dimethylammonium chloride dihydro-chloride (22.8 mmol) and 5.9 g of diisopropylethylamine (45.6 mmol) in 500 ml of ethanol. The solution is stirred at reflux for 24 hours. The product is precipitated from ethanol, filtered under hot conditions, and then dried under reduced pressure. 6 g (20.2 mmol) of compound are obtained in the form of a white powder, with a yield of 53%.

Workup

  1. temperatureat reflux for 24 hours
  2. customThe product is precipitated from ethanol
  3. filtrationfiltered under hot conditions
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-1877917bbd2f48a4974fd547c45dfa5b
Source dataset
uspto-grants-2013_11
Patent number
US08575341B2

Reaction notes

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