反应详情

2 g of 2-(1-imidazolylcarbonylamino)-6-methyl-4[1H]-pyrimidinone (9.2 mmol) are added to a solution of 2 g of N,N-bis(3-aminopropyl)-N,N′,N′,N′-tetramethylpentane-1,5-diaminium dibromide (4.6 mmol) and 1.2 g of diisopropylethylamine (9.2 mmol) in 100 ml of ethanol. The solution is stirred at reflux for 5 hours. The product is precipitated from acetone. After filtration and washing with acetone, the product is dried under reduced pressure and 3.2 g (5.5 mmol) of desired compound are obtained in the form of a white powder, with a yield of 99% (hygroscopic product).

1. temperatureat reflux for 5 hours
2. customThe product is precipitated from acetone
3. filtrationAfter filtration
4. washwashing with acetone