HRID2038173

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11056468

Benzyl 4-(2-bromoethyl)piperidine-1-carboxylate

C15H20BrNO2

结构：CCCCOc1nc(N)c2nc(OC)n(CCCC3CCCCN3C(=O)OCc3ccccc3)c2n1

HCID58306132

未命名化合物

结构：CCCCOc1nc(N)c2nc(OC)[nH]c2n1.O=C(O)C(F)(F)F

HCID178450370

未命名化合物

2 次

PRODUCTS

生成物

结构：CCCCOc1nc(N)c2nc(OC)n(CCC3CCN(C(=O)OCc4ccccc4)CC3)c2n1

HCID58306071

未命名化合物

PROCEDURE

实验过程

Prepared similarly to Intermediate 11 from 2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine trifluoroacetic acid salt (for example, as prepared for Intermediate 6) and phenylmethyl 4-(2-bromoethyl)-1-piperidinecarboxylate (for a preparation, see J. Med. Chem., 2003, 46(13), 2606).

WORKUP

后处理

customfor a preparation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-52bd87fa18fa4d9bbc6707cdd9063da1
来源数据集: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08575340B2
来源说明: uspto-grants-2013_11

反应 SMILES

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:35][CH3:36])[N:6]2[CH2:16][CH2:17][CH2:18][CH:19]1[CH2:24]CCCN1C(OCC1C=CC=CC=1)=O.FC(F)(F)C(O)=O.C(OC1N=C2C(N=C(OC)N2)=C(N)N=1)CCC.BrCCC1CC[N:67]([C:70]([O:72][CH2:73][C:74]2[CH:79]=[CH:78][CH:77]=[CH:76][CH:75]=2)=[O:71])[CH2:66][CH2:65]1>>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:35][CH3:36])[N:6]2[CH2:16][CH2:17][CH:18]1[CH2:19][CH2:24][N:67]([C:70]([O:72][CH2:73][C:74]2[CH:79]=[CH:78][CH:77]=[CH:76][CH:75]=2)=[O:71])[CH2:66][CH2:65]1