HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 4-(2-bromoethyl)piperidine-1-carboxylate → phenylmethyl 4-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 4-(2-bromoethyl)piperidine-1-carboxylate | HCID 11056468 | — |
| Reactant | Phenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate | HCID 58306132 | — |
| Reactant | HCID 178450370 | HCID 178450370 | — |
| Product | phenylmethyl 4-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate | HCID 58306071 | — |
Reaction Steps
Prepared similarly to Intermediate 11 from 2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine trifluoroacetic acid salt (for example, as prepared for Intermediate 6) and phenylmethyl 4-(2-bromoethyl)-1-piperidinecarboxylate (for a preparation, see J. Med. Chem., 2003, 46(13), 2606).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575340B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-52bd87fa18fa4d9bbc6707cdd9063da1 |
| Source note | uspto-grants-2013_11 |