2-Bromoethanol → HCID 53355055, compound

HRID 2038184Notes

Reaction equation

HRID 2038184 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]2[CH2:24][CH2:23][CH2:22][NH:21][CH2:20]2)=[C:8]([NH2:27])[N:7]=1)[CH2:2][CH2:3][CH3:4].Br[CH2:29][CH2:30][OH:31]>>[NH2:27][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:25])[N:12]2[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][N:21]([CH2:29][CH2:30][OH:31])[CH2:20]1

Participants

3

Reactant 2

HCID 108982-BromoethanolHCID 583061292-(Butyloxy)-8-(methyloxy)-9-[4-(3-piperidinyl)butyl]-9H-purin-6-amine2×

Product 1

HCID 53355055HCID 53355055, compound

Procedure

Prepared similarly to Example 1 from 2-(butyloxy)-8-(methyloxy)-9-[4-(3-piperidinyl)butyl]-9H-purin-6-amine (for example, as prepared for Intermediate 26) and 2-bromoethanol (commercially available, for example, from Aldrich).

Sources & evidence

ORD record
ord-74b0fdd57b344767a98efe692d088fdb
Source dataset
uspto-grants-2013_11
Patent number
US08575340B2

Reaction notes

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