Hydrochloric Acid → HCID 53355059, compound

Participants

Reaction Steps

2-(4-{3-[6-Amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperazinyl)ethanol (for example, as prepared for Intermediate 39) (80 mg, 0.196 mmol) was dissolved in methanol (5.5 mL) and 4M HCl in 1,4-dioxane (1.2 mL) was added. The solution was stirred at room temperature overnight, then evaporated in vacuo. The solid residue was taken up in the minimum amount of methanol and put onto a 2 g aminopropyl SPE that had been pre-conditioned with 50 mL methanol. Appropriate fractions were evaporated in vacuo to give the title compound as a white solid (68 mg).

Provenance & Evidence