Hydrochloric Acid → HCID 53355059, compound

HRID 2038188Notes

Reaction equation

HRID 2038188 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:28]C)[N:6]2[CH2:16][CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]1.Cl>CO.O1CCOCC1>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:28])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 71087171HCID 71087171, compound2×

Product 1

HCID 53355059HCID 53355059, compoundYield 88.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2-(4-{3-[6-Amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperazinyl)ethanol (for example, as prepared for Intermediate 39) (80 mg, 0.196 mmol) was dissolved in methanol (5.5 mL) and 4M HCl in 1,4-dioxane (1.2 mL) was added. The solution was stirred at room temperature overnight, then evaporated in vacuo. The solid residue was taken up in the minimum amount of methanol and put onto a 2 g aminopropyl SPE that had been pre-conditioned with 50 mL methanol. Appropriate fractions were evaporated in vacuo to give the title compound as a white solid (68 mg).

Workup

  1. customevaporated in vacuo
  2. customAppropriate fractions were evaporated in vacuo

Sources & evidence

ORD record
ord-c633c9792fd54165b0ce16c910109a51
Source dataset
uspto-grants-2013_11
Patent number
US08575340B2

Reaction notes

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