1-{[5-(3-Chloro-4-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one → 1-{[4-(3-Chloro-5-fluorophenyl)-5-(3-chlorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

HRID 2038389Notes

Reaction equation

HRID 2038389 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:13][C:12]([C:14]([N:16]3[CH2:20][C:19](=[O:21])[NH:18][CH2:17]3)=[O:15])=[N:11][C:10]=2[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=2)[CH:5]=[CH:6][C:7]=1F.ClC1C=C(C2SC(C(O)=O)=NC=2C2C=CC=C(Cl)C=2)C=CC=1[F:36]>>[Cl:28][C:24]1[CH:23]=[C:22]([C:10]2[N:11]=[C:12]([C:14]([N:16]3[CH2:20][C:19](=[O:21])[NH:18][CH2:17]3)=[O:15])[S:13][C:9]=2[C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH:27]=[C:26]([F:36])[CH:25]=1

Participants

3

Reactant 2

HCID 509429151-{[5-(3-Chloro-4-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-oneHCID 708017375-(3-Chloro-4-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid

Product 1

HCID 509429161-{[4-(3-Chloro-5-fluorophenyl)-5-(3-chlorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 4 starting with the compound from Example 11A. 4.5 mg (19% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-a25d73920c5a483ba99ff3e45f0b18e6
Source dataset
uspto-grants-2013_11
Patent number
US08575357B2

Reaction notes

Loading…