5-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}-2-fluorobenzenecarbonitrile → 3-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}benzenecarbonitrile

HRID 2038390Notes

Reaction equation

HRID 2038390 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([C:22]([N:24]3[CH2:28][C:27](=[O:29])[NH:26][CH2:25]3)=[O:23])[S:11][C:12]=2[C:13]2[CH:14]=[CH:15][C:16](F)=[C:17]([C:19]#[N:20])[CH:18]=2)[CH:5]=[CH:6][CH:7]=1.BrC1SC(C(N2CC(=O)NC2)=O)=NC=1C1C=CC(F)=C(Cl)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([C:22]([N:24]3[CH2:28][C:27](=[O:29])[NH:26][CH2:25]3)=[O:23])[S:11][C:12]=2[C:13]2[CH:18]=[C:17]([C:19]#[N:20])[CH:16]=[CH:15][CH:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 703152005-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}-2-fluorobenzenecarbonitrileHCID 708015141-{[5-Bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Product 1

HCID 509429183-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}benzenecarbonitrile

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 5 starting with the compound from Example 7A. 12.0 mg (22% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-9e2a2ebeb4a841b3afb5988a06432f1f
Source dataset
uspto-grants-2013_11
Patent number
US08575357B2

Reaction notes

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