HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}-2-fluorobenzenecarbonitrile → 3-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}benzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}-2-fluorobenzenecarbonitrile | HCID 70315200 | — |
| Reactant | 1-{[5-Bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one | HCID 70801514 | — |
| Product | 3-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}benzenecarbonitrile | HCID 50942918 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 5 starting with the compound from Example 7A. 12.0 mg (22% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575357B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-9e2a2ebeb4a841b3afb5988a06432f1f |
| Source note | uspto-grants-2013_11 |