HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Chloro-4-fluorophenyl)-5-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid → 5-{4-(3-Chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}-2-fluorobenzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Chloro-4-fluorophenyl)-5-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid | HCID 67568353 | — |
| Reactant | 5-{4-(3-Chlorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}-2-fluorobenzenecarbonitrile | HCID 70315200 | — |
| Product | 5-{4-(3-Chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}-2-fluorobenzenecarbonitrile | HCID 50942988 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 5 starting with the compound from Example 15A. 17.3 mg (35% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575357B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-0e1152a4458046828ee40aabf9b6dd7e |
| Source note | uspto-grants-2013_11 |