反应详情

45.0 mg of the compound from Example 32A having a purity of 61% (0.075 mmol), 16.5 mg (0.082 mmol) of the compound from Example 20A and 58.3 mg (0.112 mmol) of PyBOP are provided in 3 ml of tetrahydrofuran, and 42 μl (0.239 mmol) of N,N-diisopropylethylamine are added at room temperature. The reaction solution is stirred at room temperature overnight, diluted with dichloromethane and subsequently washed with a 1N aqueous hydrogen chloride solution. The organic phase is dried over magnesium sulfate, filtered and concentrated under reduced pressure, acetonitrile is then added to the crude product and the solid formed is subsequently collected by filtration. 17.4 mg (53% of theory) of the title compound are obtained.

1. washsubsequently washed with a 1N aqueous hydrogen chloride solution
2. dry with materialThe organic phase is dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure, acetonitrile
5. additionis then added to the crude product
6. customthe solid formed
7. filtrationis subsequently collected by filtration