Trifluoroacetic acid → HCID 67289029, compound

HRID 2038402Notes

Reaction equation

HRID 2038402 reaction equation
[C:1]([N:9]1[CH2:13][CH2:12][C@H:11]([N:14](C)[C:15](=O)OC(C)(C)C)[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:15][NH:14][C@H:11]1[CH2:12][CH2:13][N:9]([C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:8])[CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67473782HCID 67473782, compound

Product 1

HCID 67289029HCID 67289029, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 4c (0.12 g, 0.394 mmol) in CH2Cl2 (3 mL) was added trifluoroacetic acid (1 mL) at room temperature. The mixture was stirred at room temperature for 5 h. The solvent was removed by evaporation. Ether (10 mL) was added to the residue. The crude product was collected by filtration, washed with ether, and dried under vacuum. MS m/z (M+H+) 205.2.

Workup

  1. customThe solvent was removed by evaporation
  2. additionEther (10 mL) was added to the residue
  3. filtrationThe crude product was collected by filtration
  4. washwashed with ether
  5. customdried under vacuum

Sources & evidence

ORD record
ord-7c8fbbff8e914e0cb6a0eed1350f0efb
Source dataset
uspto-grants-2013_11
Patent number
US08575363B2

Reaction notes

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