反应详情

To a solution of compound 5d (0.96 g, 2.78 mmol) in MeOH (5 mL) was added HCl solution in dioxane (4M, 10 mL) at room temperature. The mixture was stirred at room temperature for 4 h. The solvent was removed by evaporation. Ether (50 mL) was added to the residue. The off-white solid was collected by filtration, washed with hexanes, and dried under vacuum. The crude compound 5e was used in the next reaction without further purification. MS m/z (M+H+) 246.0.

1. customThe solvent was removed by evaporation
2. additionEther (50 mL) was added to the residue
3. filtrationThe off-white solid was collected by filtration
4. washwashed with hexanes
5. customdried under vacuum
6. customThe crude compound 5e was used in the next reaction without further purification