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HRID2038676

反应详情

EQUATION

反应方程式

HRID 2038676 的结构方程式

REACTANTS

反应物

2
结构：O=Cc1cccc(O)c1
HCID101

3-Hydroxybenzaldehyde

C7H6O2

结构：Br.Br.Br.CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCNC4)n[nH]c2c1
HCID178419240

5-Ethyl-2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazol[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt

C21H23Br3FN5O

PRODUCTS

生成物

1
结构：CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccc(O)c3)C4)n[nH]c2c1
HCID178436905

未命名化合物

收率 62%

PROCEDURE

实验过程

The title compound was prepared from 3-hydroxy-benzaldehyde (24.2 mg, 198 μmol) and 5-ethyl-2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt (Preparation 25, 50 mg, 132 μmol) using the method of Example 18. The crude material was purified by HPLC Method A to afford 39.6 mg of the title compound.

WORKUP

后处理

  1. customThe crude material was purified by HPLC Method A