Hydrochloric Acid → HCID 178436891, compound

HRID 2038726Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C:11]2[N:14](COCC[Si](C)(C)C)[C:15]([C:17]3[C:25]4[C:20](=[CH:21][C:22]([C:26]5[CH:31]=[C:30]([F:32])[C:29]([O:33][CH3:34])=[CH:28][C:27]=5[CH2:35][CH3:36])=[CH:23][CH:24]=4)[N:19](C4CCCCO4)[N:18]=3)=[N:16][C:10]=2[CH2:9]1)=O)(C)(C)C.[ClH:51]>CO>[ClH:51].[ClH:51].[ClH:51].[CH2:35]([C:27]1[CH:28]=[C:29]([O:33][CH3:34])[C:30]([F:32])=[CH:31][C:26]=1[C:22]1[CH:21]=[C:20]2[C:25]([C:17]([C:15]3[NH:14][C:11]4[CH2:12][CH2:13][NH:8][CH2:9][C:10]=4[N:16]=3)=[N:18][NH:19]2)=[CH:24][CH:23]=1)[CH3:36]

Participants

Conditions

Temperature: 60 °C

Procedure

To a solution of 2-[6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-3-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester (Preparation 23, 801 mg, 1.13 mmol) in methanol (20 mL) was added concentrated hydrochloric acid (12M, 8 mL) and the resulting solution was heated at 60° C. for 18 hours. The reaction mixture was cooled to room temperature and concentrated in vacuo to furnish the title compound (739 mg).

Workup

temperatureThe reaction mixture was cooled to room temperature
concentrationconcentrated in vacuo

Sources & evidence

ORD record: ord-1d66657dcbbb41eaa23264c41b5f0f94
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575336B2

Reaction notes

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