Hydrochloric Acid → HCID 68379085, compound

HRID 2038777Notes

Reaction equation

HRID 2038777 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[N:12]=[N:13][C:14]([C:17]3[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=3)=[CH:15][CH:16]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:24].O1CCOCC1>C(Cl)Cl>[ClH:24].[ClH:24].[CH3:22][N:20]1[CH:21]=[C:17]([C:14]2[N:13]=[N:12][C:11]([C:8]3([NH2:7])[CH2:10][CH2:9]3)=[CH:16][CH:15]=2)[CH:18]=[N:19]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67515128HCID 67515128, compound

Product 1

HCID 68379085HCID 68379085, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

{1-[6-(1-Methyl-1H-pyrazol-4-yl)-pyridazin-3-yl]-cyclopropyl}-carbamic acid tert-butyl ester (51 mg, 0.16 mmol) was dissolved in CH2Cl2 (1 mL) and 4M HCl in dioxane (2 mL, 4 mmol) was added. After 2 h, the solvents removed under a stream of N2 to give the title compound as an orange solid, m/z=216.4 [M+H]+.

Workup

  1. customthe solvents removed under a stream of N2

Sources & evidence

ORD record
ord-a71416eb08f043e993790e14e3462856
Source dataset
uspto-grants-2013_11
Patent number
US08575360B2

Reaction notes

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