1,4-Dioxane hydrochloride → HCID 68379297, compound

HRID 2038779Notes

Reaction equation

HRID 2038779 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:10](=[O:26])[NH:11][C:12]1([C:15]2[N:16]=[N:17][C:18]([C:21]3[CH:22]=[N:23][NH:24][CH:25]=3)=[CH:19][CH:20]=2)[CH2:14][CH2:13]1)[CH3:9])(C)(C)C.O1CCOCC1.[ClH:34]>C(Cl)Cl>[ClH:34].[ClH:34].[NH2:7][C@@H:8]([CH3:9])[C:10]([NH:11][C:12]1([C:15]2[N:16]=[N:17][C:18]([C:21]3[CH:22]=[N:23][NH:24][CH:25]=3)=[CH:19][CH:20]=2)[CH2:14][CH2:13]1)=[O:26]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68378994HCID 68378994, compound

Product 1

HCID 68379297HCID 68379297, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

((S)-1-{1-[6-(1H-pyrazol-4-yl)-pyridazin-3-yl]-cyclopropylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester was dissolved in CH2Cl2 (1.0 mL) and 4M HCl dioxane (2 mL, 8 mmol) was added. After 1.5 h, the solvents were removed at 50° C. under a stream of N2. This material was dried under vacuum to yield 73 mg of the title compound, m/z 273.5 [M+H]+.

Workup

  1. customthe solvents were removed at 50° C. under a stream of N2
  2. customThis material was dried under vacuum

Sources & evidence

ORD record
ord-8f911c961b4a493fb9607c85cd3c55a3
Source dataset
uspto-grants-2013_11
Patent number
US08575360B2

Reaction notes

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