反应详情

To a solution of (R)-(+)-2-methyl-2-propanesulfinamide (2.60 g, 21.5 mmol) in 100 mL of CH2Cl2 at room temperature was added CuSO4 (7.53 g, 47.2 mmol) and 5-bromo-pyridine-2-carbaldehyde (4.39 g, 23.6 mmol). The reaction mixture was stirred at room temperature for 21 h and then filtered through Diatomaceous earth, washing with CH2Cl2. The filtrates were concentrated to give a pale brown oil that was purified by flash chromatography on silica gel, eluting with 10-25% EtOAc in hexanes, to afford 6.04 g (97%) of (R)-2-methyl-propane-2-sulfinic acid 1-(5-bromo-pyridin-2-yl)-meth-(E)-ylideneamide as a pale yellow solid.

1. filtrationfiltered through Diatomaceous earth
2. washwashing with CH2Cl2
3. concentrationThe filtrates were concentrated
4. customto give a pale brown oil that
5. customwas purified by flash chromatography on silica gel
6. washeluting with 10-25% EtOAc in hexanes