Hydrochloric Acid → HCID 178494463, compound

HRID 2038887Notes

Reaction equation

[CH3:1][O:2][C:3]([NH:5][C@H:6]([C:10]([N:12]1[CH2:16][CH:15]([CH2:17][O:18][CH3:19])[CH2:14][CH:13]1[C:20]1[NH:24][C:23]2[C:25]3[C:30]([CH:31]=[CH:32][C:22]=2[N:21]=1)=[CH:29][C:28]1[C:33]2[C:38]([CH2:39][O:40][C:27]=1[CH:26]=3)=[CH:37][C:36]([C:41]1[NH:45][C:44]([CH:46]3[CH2:50][CH:49]([CH3:51])[CH2:48][N:47]3C(OC(C)(C)C)=O)=[N:43][CH:42]=1)=[CH:35][CH:34]=2)=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4].Cl>C(O)C>[CH3:19][O:18][CH2:17][CH:15]1[CH2:16][N:12]([C:10](=[O:11])[CH:6]([NH:5][C:3](=[O:4])[O:2][CH3:1])[CH:7]([CH3:9])[CH3:8])[CH:13]([C:20]2[NH:24][C:23]3[C:25]4[C:30]([CH:31]=[CH:32][C:22]=3[N:21]=2)=[CH:29][C:28]2[C:33]3[C:38]([CH2:39][O:40][C:27]=2[CH:26]=4)=[CH:37][C:36]([C:41]2[NH:45][C:44]([CH:46]4[CH2:50][CH:49]([CH3:51])[CH2:48][NH:47]4)=[N:43][CH:42]=2)=[CH:35][CH:34]=3)[CH2:14]1

Participants

Conditions

Temperature: 60 °C

Procedure

tert-butyl 2-[5-(2-{1-[N-(methoxycarbonyl)valyl]-4-(methoxymethyl)pyrrolidin-2-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carboxylate (50 mg, 0.063 mmol) was treated with 2 mL 1.25N HCl in ethanol and heated at 60° C. for 2 h, then it was concentrated under reduced pressure and pumped dry under high vacuum and used directly in the next step.

Workup

concentrationit was concentrated under reduced pressure
custompumped dry under high vacuum

Sources & evidence

ORD record: ord-1f7db094fa63479ea093a6e60638d725
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575135B2

Reaction notes

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