HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → HCID 68560967, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 68559633 | HCID 68559633 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68560967 | HCID 68560967 | — |
Reaction Steps
Dissolve (R)-5-(tert-butyldimethylsilanyloxymethyl)-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester (0.39 g, 1.04 mmol) in tetrahydrofuran (3 mL) and add tetrabutylammonium fluoride (2.1 mL, 2.1 mmol, 1.0 M in tetrahydrofuran). Stir 45 minutes at room temperature and concentrate. Purify on silica gel, eluting with 10:90 to 40:60 ethyl acetate in hexanes to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745438B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-84489890e1a944df9934c14a80fa0552 |
| Source note | uspto-grants-2010_06 |