反应详情

Dissolve (R)-5-(tert-butyldimethylsilanyloxymethyl)-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester (0.39 g, 1.04 mmol) in tetrahydrofuran (3 mL) and add tetrabutylammonium fluoride (2.1 mL, 2.1 mmol, 1.0 M in tetrahydrofuran). Stir 45 minutes at room temperature and concentrate. Purify on silica gel, eluting with 10:90 to 40:60 ethyl acetate in hexanes to give the desired compound.

1. concentrationconcentrate
2. customPurify on silica gel
3. washeluting with 10:90 to 40:60 ethyl acetate in hexanes