Phenyltrimethylammonium bromide dibromide → HCID 58545558, compound

HRID 2039238Notes

Reaction equation

HRID 2039238 reaction equation
[S:1]1[C:5]([C:6](=[O:8])[CH3:7])=[CH:4][CH:3]2[S:9][CH:10]=[CH:11][CH:2]12.[Br-:12].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1>C1COCC1>[Br:12][CH2:7][C:6]([C:5]1[S:1][CH:2]2[CH:11]=[CH:10][S:9][CH:3]2[CH:4]=1)=[O:8]

Participants

4

Reactant 2

HCID 17977687Phenyltrimethylammonium bromide dibromideHCID 58545574HCID 58545574, compound

Product 1

HCID 58545558HCID 58545558, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-(3a,6a-Dihydro-thieno[3,2-b]thiophen-2-yl)-ethanone (453 mg, 2.48 mmol) was dissolved in THF (12 mL) and phenyltrimethylammonium tribromide (932 mg, 2.48 mmol) was added. After stirring for 1 h, the suspension was filtered over CELITE. The filtrate was diluted with diethyl ether, then washed with saturated aqueous NaHCO3 and brine then dried over MgSO4, filtered and concentrated to afford the title compound which was carried on without purification.

Workup

  1. filtrationthe suspension was filtered over CELITE
  2. additionThe filtrate was diluted with diethyl ether
  3. washwashed with saturated aqueous NaHCO3 and brine
  4. dry with materialthen dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-f6e5297de63a4dcca826a800c9fcdf58
Source dataset
uspto-grants-2013_11
Patent number
US08575118B2

Reaction notes

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