Triethyl phosphite → Diethyl (4-Bromobenzyl)phosphonate

HRID 2039412Notes

Reaction equation

HRID 2039412 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[P:10]([O:17]CC)([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 685274-Bromobenzyl bromide

Product 1

HCID 11077666Diethyl (4-Bromobenzyl)phosphonate

Procedure

40.69 g (1 molar equivalent, 163 mmol) of 4-bromobenzyl bromide 1 are heated at 160° C. in 28.3 ml (1 molar equivalent, 163 mmol) of triethyl phosphite until the evolution of gas is complete. The batch is distilled in vacuo, and the residue remaining in the form of an oil 2 (48.87 g, 98%) is employed in the subsequent reaction without further purification.

Workup

  1. distillationThe batch is distilled in vacuo
  2. customis employed in the subsequent reaction without further purification

Sources & evidence

ORD record
ord-57803490aa25423897ffcd1a9902dc71
Source dataset
uspto-grants-2013_11
Patent number
US08580395B2

Reaction notes

Loading…