Triethyl phosphite → Diethyl (4-Bromobenzyl)phosphonate

Participants

Reaction Steps

40.69 g (1 molar equivalent, 163 mmol) of 4-bromobenzyl bromide 1 are heated at 160° C. in 28.3 ml (1 molar equivalent, 163 mmol) of triethyl phosphite until the evolution of gas is complete. The batch is distilled in vacuo, and the residue remaining in the form of an oil 2 (48.87 g, 98%) is employed in the subsequent reaction without further purification.

Provenance & Evidence