反应详情

Firstly, 100 g (0.5 mol) of 2-tridecanone (Aldrich P/N 17,283-9), 56 g (0.6 mol) of glycerol (Aldrich P/N 32,00-5), 200 mL of benzene, and 1.8 grams of p-toluenesulfonic acid (Aldrich P/N 40,2885) were placed in a 500 mL round bottom flask fitted with a Dean Stark apparatus. The mixture was heated to reflux with stirring until no further separation of water appeared. The reaction mixture was cooled to room temperature and washed successively with a 100 mL portion of 5% sodium carbonate solution and three 100 mL portions of water. The organic layer was dried over sodium sulfate, filtered and the benzene was removed with a rotary evaporator. The residual oil was fractionated by distillation under reduced pressure to give the desired product (b.p. 140° C./0.3 mm Hg). The identity of the product was confirmed by 1H NMR in CDCl3.

1. customfitted with a Dean Stark apparatus
2. temperatureThe mixture was heated
3. temperatureto reflux
4. washwashed successively with a 100 mL portion of 5% sodium carbonate solution and three 100 mL portions of water
5. dry with materialThe organic layer was dried over sodium sulfate
6. filtrationfiltered
7. customthe benzene was removed with a rotary evaporator
8. distillationThe residual oil was fractionated by distillation under reduced pressure