反应详情

To a solution of 5-(3-nitro-benzyl)-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine (0.10 g, 0.31 mmol), prepared as described in Example 2, in N,N-dimethylformamide (10 mL), 10% Pd/C (50% w/w, 0.05 g) was added. The mixture was reacted in Parr Apparatus at 40 p.s.i. for 5 h. The suspension was filtered through Celite®. After washing the filter with methanol, the solution was evaporated to dryness. The crude was twice crystallized from ethyl acetate to provide the title product (0.062 g, 67% yield).

1. customThe mixture was reacted in Parr Apparatus at 40 p.s.i
2. filtrationThe suspension was filtered through Celite®
3. washAfter washing the
4. filtrationfilter with methanol
5. customthe solution was evaporated to dryness
6. customThe crude was twice crystallized from ethyl acetate