Trifluoroacetic acid → HCID 51037107, compound

Participants

Reaction Steps

To a suspension of [(R)-(2-amino-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-phenyl-methyl]-carbamic acid tert-butyl ester (0.05 g, 0.13 mmol), prepared as described in Example 49, in dichloromethane (4 mL), trifluoroacetic acid (1 mL) was added. The mixture was stirred at room temperature for 1 h, then the solvent was evaporated and the residue was diluted with ethyl acetate and washed with NaHCO3 satured solution then with water and brine. The organic phase was dried over Na2SO4, filtered and evaporated to provide the title compound (0.02 g, 65% yield).

Provenance & Evidence